Loop diuretics inhibit the bodys ability to reabsorb sodium at the ascending loop in the kidney which leads to a retention of water in the urine. If, like loop diuretics, maximal fractional sodium excretion remains constant as gfr declines, then their already modest ceiling will appear minimal when gfr is low. Download pharmacology books pdf free all medical stuff. Mechanisms of action, pharmacological effects and clinical indications of diuretic compounds.
Receive instant access to 720 more quiz questions by registering with pharmafactz today. Choose from 500 different sets of pharmacology quiz 1 diuretics flashcards on quizlet. Jan 06, 2018 these substances increase the excretion of water, sodium, and chloride through urine. Diuretics pharmacology med vids made simple youtube. Starting with the physiology of the kidney, it progresses to explain how diuretics actually work, via symports on the inside of the renal tubules.
Other diuretics exert osmotic effects that prevent water reabsorption mannitol, inhibit enzymes acetazolamide, or interfere with hormone receptors in renal epithelial. View and download powerpoint presentations on heart failure pharmacology ppt. Ppt diuretics powerpoint presentation free to download. There are chances that diuretics may reduce the secretion of uric acid. Why diuretics should be used in heart failure how they improve symptoms and outcomes how to start and titrate the dose what the possible side effects are and what to do about them activation of the raas by the failing heart leads to fluid and salt retention. Reducing the amount of fluid in the blood vessels results in reduction in blood pressure. Diuretics, commonly called water pills, are drugs that promote diuresis, that is increased production of urine. The subgroups of the sodiumexcreting diuretics are based on these sites and processes in the nephron.
Diuretic a diuretic is any substance that promotes diuresis, the increased production of urine. As part of your naplex exam, or other clinical pharmacy exam, you will be asked many questions on diuretics. Diureticdrugsfornursingpharmacology diuretic agents. I think mike cruickshanks new profit maximiser service is going to be one of the big hits and i can say hand on heart, if you follow the instructions, and just get involved, you will make a lot of money over the coming weeks, months and years. They exert most of their therapeutic effects through inhibiting the reabsorption of sodium at different sites along the nephron of the kidney. The following discussion and accompanying illustration provide a simple overview of how the kidney handles water and electrolytes. Bilal mirza 4th year download in your computer according to site of action and mechanism of action. Which of the following is a potassium losing diuretic. Anatomy physiology biochem pathology pharmacology microbiology forensic ophthalmology e n t medicine gynaecology obstetrics surgery paediatrics and many more subjects ready made power point presentations. Other side effects include gout, which results from raised uric acid levels hyperuricaemia table 2, fig. Diuretic agents classification drug indications actions adverse effects contraindications drug drug thiazide diuretics hydrochlorothiazide hydrodiuril treatment of edema caused by congestive heart failure chf, liver disease, or renal disease, and for adjunctive treatment of hypertension block the chloride pump keep the chloride and sodium in the tubule to be excreted in the urine, thus. Describes pharmacology of diuretic drugs authorstream presentation. Download pharmacology powerpoint lectures download free online book chm pdf.
Used widely in the community, hospitals and icu, diuretics are an incredibly common medication so you will be asked about them in nearly every. Diuretics are used in the treatment of conditions such as hypertension, heart failure and cirrhosis. If so, share your ppt presentation slides online with. View diuretic drugs ppts online, safely and virusfree. Alright, now in this part of the article, you will be able to access the free pdf download of fundamentals of pharmacology 7th edition pdf using our direct links mentioned at the end of this article. All diuretics increase the excretion of water from bodies. Thiazide and thiazidelike diuretics are the second most commonly prescribed class of antihypertensive agents. The drugs covered in this unit have a variety of mechanisms of action including diuresis, sympathoplegia, vasodilation, and antagonism of angiotensin, and many agents are available in most categories. Diuretics are drugs that promote diuresis, or increased urine production.
Choose from 500 different sets of pharm test pharmacology nurses diuretic flashcards on quizlet. Drug inducing state of increased urine flow ion transport inhibitors, decrease reabsorption of sodium at different sites in the nephron sodium and other ions such as chloride enter the urine in greater amounts than normal along with water, which is carried passively to. Pharmacology of diuretics free download as powerpoint presentation. The loop diuretics furosemide, bumetanide, and torsemide act from the lumen to inhibit the nak2cl cotransporter nkcc2, encoded by slc12a1 along the thick ascending limb and. Several other drugs alter water excretion predominantly. Although the available diuretic drugs possess distinctive pharmacokinetic and.
The effects of the diuretic agents are predictable from knowledge of the function of the segment of the nephron in which they act. Each type works in a distinct way and in different parts of the kidney. Other diuretics exert osmotic effects that prevent water reabsorption mannitol. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and development and the testing of their action in the body. Diureticsmechanism of action,diuretic types and adverse. View and download powerpoint presentations on diuretics ppt. Diuretic drugs clarise elefante shirley garay daniel alexei garcia 2. Many diuretics exert their effects on specific membrane transport proteins in renal tubular epithelial cells. Nursing 3703 pharmacology antimicrobials by linda self microorganisms and infections microbes attach to host receptors attracted to a specific body tissue, invade and. Fundamentals of pharmacology 7th edition pdf free download.
These ten questions test your knowledge about the essential, core facts that you, as a student, are expected to know. Lecture clinical pharmacology of diuretics about open. Thus, the initial natriuresis typically wanes within 36 hours, so that a single daily dose leaves some. Diuretics drs mathijs department of pharmacology what is a diuretic. Powerpoint slide on diuretics compiled by prashant nandkumar amale. General pharmacology renal handling of sodium and water. Loop diuretics are characterized by relatively short t 12 see table 2. Find powerpoint presentations and slides using the power of, find free presentations research about diuretics ppt. The major transport mechanisms for the recovery of ions and water in the various segments of the nephron are shown in figure 151. Download figure open in new tab download powerpoint. Contraindications, side effects and interaction with other drugs of this group are discussed in detail. Set 1 powerpoint links collected from the website of.
If playback doesnt begin shortly, try restarting your. Moa, indications, side effects and therapeutic considerations author. Antidiuretic drugs market is expected to grow at a cagr of 9. Pharmacology of diuretics authorstream presentation. Diuretics pharmacology clinical details for pharmacy. Clinical pharmacology all diuretics except spironolactone exert their effects from the lumen of the nephron. Nov 30, 2017 i think mike cruickshanks new profit maximiser service is going to be one of the big hits and i can say hand on heart, if you follow the instructions, and just get involved, you will make a lot of money over the coming weeks, months and years. Thus, diuretics continue to be widely used for the management of hypertension. This article discusses the mechanisms of action, pharmacological effects and clinical indications of the various diuretic classes used in everyday clinical practice, with emphasis on recent knowledge suggesting beneficial effects of certain diuretics on clinical conditions distinct from the traditional indications. Diuretic ppt free download as powerpoint presentation. Because the mechanisms for reabsorption of salt and water differ in. Learn pharm test pharmacology nurses diuretic with free interactive flashcards. Clinical pharmacology of diuretics in the international system of atc anatomictherapeuticchemical is presented. Edwin jackson and were published in the division for cardiovascular pharmacology, a branch of the american society for pharmacology and experimental therapeutics.
Chronic renal failure nephrotic syndrome cirrhosis mild chf moderate or severe chf loop diuretic. Learn vocabulary, terms, and more with flashcards, games, and other study tools. A free powerpoint ppt presentation displayed as a flash slide show on id. Loop diuretics are diuretics that act at the ascending limb of the loop of henle in the kidney. Jun 08, 2019 diuretics are drugs that primarily increase the excretion of sodium. S2 has acid secretory mechanism which is important in the secretion of weak acids like diuretics, nsaids, uric acid, antibiotics penicillin, cephalosporins and forms basis of drug interactions of diuretics with uric acid. Titrate single daily dose up to ceiling dose as needed thiazide diuretic. Classification of this group by the action mechanism and caused effects is provided. Mar 31, 2017 nearly all the diuretics work by this principle. Choose from 500 different sets of pharmacology diuretics flashcards on quizlet. Learn pharmacology quiz 1 diuretics with free interactive flashcards. All but spironolactone must reach the lumen or urinary side of the nephron to exert their effects. Mechanism of action inhibit tubular resorption of sodium and chloride ions action primarily in the ascending loop of henle and early distal tubule result.
Learn pharmacology diuretics with free interactive flashcards. Scribd is the worlds largest social reading and publishing site. The second section describes the pharmacology of diuretic agents. A single renin inhibitor has recently been added to the drugs used in. Diuretics play an important role in the management of high blood pressure. Crcl 50, use 25 to 50 mgd hctz crcl 20 to 50, use 50 to 100 mgd hctz crcl diuretic. Jul 19, 2018 in this video, we have explained all the things you need to know about diuretics. Pharmacology and clinical use of diuretics katie herndon, pharm. Pharmacokinetics and pharmacodynamics features, indications and principles of diuretics usage in clinics are considered. Diuretic drugs are typically classified first according to their predominant site of action along the nephron and second by the mechanism by which they inhibit transport.
Antihypertensive drugs basic concepts in pharmacology. Antihypertensive drugs are organized around a clinical indicationthe need to treat a diseaserather than a receptor type. Ivmscv pharmacology diuretic agents authorstream presentation. The diuretics in our therapeutic armamentarium have predictable effects based on their nephron sites of action. The british national formulary bnf currently lists 15 individual diuretics available for use in the uk but the original one, chlorothiazide, is not among them, although its derivatives, hydrochlorothiazide and benzothiazide, do feature in combination preparations. We are currently in the process of making more videos on pharmacology and all subjects in medical school. This book aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. Diuretics are drugs that primarily increase the excretion of sodium. Diuretic agents increase the urine formation, by influencing any of the processes involved in urine formation. Fifty years of thiazide diuretic therapy for hypertension. The kidney filters plasma water and solutes at the glomerulus at a very high rate 180 lday and must recover a significant percentage of most of these substances before excretion in the urine. Loop diuretics act on the loop of henle in the kidney and prevent reabsorption of water and salt. To some extent, they also increase the volume of urine produced by the kidneys by blocking the absorptive capacity of cells lining the renal tubules for sodium, intravascular volume and the eventual leaking of fluid from capillaries is reduced and prevented. Conns syndrome, ectopic acth production of secondary aldosteronism e.
The following set of lectures has been created by dr. Clinical pharmacology in diuretic use american society. Diuretics mechanism of action, diuretic types and adverse effects,drug specifications 1. To download files right click on the link and select save target as or save link as. The addition of theophylline resulted in reduced local reaction at the site of injection. Find powerpoint presentations and slides using the power of, find free presentations research about heart failure pharmacology ppt. Crcl 50, use 25 to 50 mgd hctz crcl 20 to 50, use 50 to 100 mgd hctz crcl 75. Inhibits nak2cl transporter in thick ascending loop of henle. Diuretics also called water pills are drugs that increase urine production in the kidneys, promoting the removal of salt and fluid from the body. The reason i place this book here is the lot of requests i received for this book. Increase the urine flow, change urine ph change the ionic composition of the urine and blood.
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